HISTOLOGICAL CHANGES OF EPITHELIAL AND CONNECTIVE TISSUES IN CHRONIC INFLAMMATORY DISEASES AND THEIR CLINICAL SIGNIFICANCE

Authors

  • Kurbanova Nilufar Senior Lecturer at the Department of Medical Biology and Histology

Keywords:

Histology, chronic inflammation, epithelial tissue, connective tissue, fibrosis, clinical significance

Abstract

Chronic inflammatory diseases are characterized by persistent tissue damage and repair processes that result in distinct histological alterations of epithelial and connective tissues. These structural changes play a crucial role in disease progression, organ dysfunction, and clinical outcomes. This article aims to analyze the histological features of epithelial and connective tissues in chronic inflammatory conditions and to evaluate their clinical significance. The findings demonstrate that epithelial degeneration, altered regeneration, connective tissue fibrosis, and chronic inflammatory cell infiltration are key morphological hallmarks with important diagnostic and prognostic implications.

References

Kumar V, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease. 10th ed. Elsevier; 2020.

Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease. Saunders; 2015.

Medzhitov R. Inflammation 2010: New adventures of an old flame. Cell. 2010;140:771–776.

Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214:199–210.

Rockey DC, et al. Fibrosis—a common pathway to organ injury. N Engl J Med. 2015;372:1138–1149.

Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. Elsevier; 2018.

Stricker TP, Kumar V. Neoplasia and epithelial dysplasia. Pathology. 2016;48:135–145.

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Published

2025-12-27

How to Cite

Kurbanova Nilufar. (2025). HISTOLOGICAL CHANGES OF EPITHELIAL AND CONNECTIVE TISSUES IN CHRONIC INFLAMMATORY DISEASES AND THEIR CLINICAL SIGNIFICANCE. Ethiopian International Journal of Multidisciplinary Research, 12(12), 1167–1169. Retrieved from https://eijmr.org/index.php/eijmr/article/view/4429