THE EFFECT OF NIGELLA  SATIVA OIL ON THE MORPHOLOGICAL STRUCTURE OF RENAL TISSUES IN GENTAMICIN-INDUCED NEPHROTOXICITY

Ibragimova Ziyodaxon Jalolidinovna

Authors

Ibragimova Ziyodaxon Jalolidinovna Fergana medical institute of public health

Keywords:

Gentamicin, Nephrotoxicity, Nigella sativa oil, Morphological changes, Tubular necrosis, Glomerular damage, Interstitial inflammation, Histopathological examination.

Abstract

Gentamicin, a widely used aminoglycoside antibiotic, is known to cause nephrotoxicity as a major side effect, limiting its clinical application. This study aimed to evaluate the protective effect of Nigella sativa oil on gentamicin-induced nephrotoxicity by assessing the morphological changes in renal tissues in an experimental rat model. Rats were divided into control, gentamicin-treated, and gentamicin plus Nigella sativa oil-treated groups. Histopathological examination revealed severe tubular necrosis, glomerular damage, and interstitial inflammation in the gentamicin group. In contrast, co-administration of Nigella sativa oil significantly reduced these histological alterations, indicating improved renal morphology. The findings suggest that Nigella sativa oil exerts nephroprotective effects, likely through its antioxidant and anti-inflammatory properties, and could be considered a potential therapeutic agent against gentamicin-induced renal injury. Further research is necessary to elucidate the underlying molecular mechanisms and clinical applicability.

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