OPTICONEUROMYELITIS SPECTRUM DISEASE: A LITERARY REVIEW
Keywords:
Devik's disease; antibodies to aquaporin-4; literature review, optic nerve damage, spinal cord damage.Abstract
An analytical review of modern literature on epidemiology, pathogenesis, pathomorphology, clinic, diagnosis and treatment of Devik's disease (opticoneuromyelitis) is presented. The characteristic neurological symptoms of spinal cord and optic nerve damage are summarized. The diagnostic criteria of Devik's disease and opticomyelitis-associated disorders are presented. Spinal cord MRI disorders typical of Devic's disease have been studied. The high diagnostic significance of the antibody titer to aquaporin-4 has been shown. Promising directions are presented prevention of relapses with monoclonal antibodies.
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