DIRECT THROMBIN INHIBITORS COMPARISON
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xxxxxxxxxxxxxxAbstract
Direct thrombin inhibitors inactivate circulating and clot-bound thrombin (factor IIa). This may be especially important in individuals with coronary thrombosis. Unlike heparin, the direct thrombin inhibitors do not bind to platelet factor 4 (PF4) and thus are not able to induce or react with the anti-heparin/PF4 antibodies that cause heparin-induced thrombocytopenia (HIT). Thus, the parenteral direct thrombin inhibitors are options for anticoagulation in patients with HIT.
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