PRENATAL ETHANOL EXPOSURE AS A RISK FACTOR FOR IMMUNE DYSREGULATION AND COMPLICATED POSTOPERATIVE COURSE IN PEDIATRIC SURGERY
Keywords:
prenatal ethanol exposure, pediatric surgery, immune dysregulation, thymus, spleen, postoperative complications, wound healing, Tashkent Medical Institute clinic.Abstract
The clinical outcome of pediatric surgical diseases is determined not only by the anatomical pathology and the technical success of the operation, but also by the child’s immune reserve. Prenatal exposure to ethanol may disturb fetal organogenesis and may negatively affect the maturation of lymphoid organs. In this context, the thymus and spleen are important because they participate in T-lymphocyte maturation, immune surveillance, inflammatory regulation and postoperative tissue repair. Structural or functional weakness of these organs may reduce resistance to infection and may worsen recovery after surgery.
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