THE NEUTROPHIL AND CLINICAL CHARACTERISTICS OF POST-COVID PNEUMONIA
Keywords:
viral infection, immune cell, neutrophil, SARS-COVID-19 infectionAbstract
Unusually for a viral infection, the immunological phenotype of post-COVID-19 patients is characterised by a depleted lymphocyte and elevated neutrophil count, with the neutrophil-to-lymphocyte ratio correlating with disease severity. Neutrophils are the most abundant immune cell in the bloodstream and comprise different subpopulations with pleiotropic actions that are vital for host immunity. Neutrophils also contribute to complications of post- COVID-19 such as thrombosis, acute respiratory distress syndrome and multisystem inflammatory disease in children. In this Progress review, we discuss the anti-viral and pathological roles of neutrophils in SARS-COVID-19 infection.
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