REGENERATION-ACTIVATING ROLE OF 6-AMINOPURINE IN A BIODEGRADABLE COLLAGEN–HYDROGEL SYSTEM

Abdumajid Arabov; Foziljon Saitkulov; Akbar Abdinazarov; Kuchkar Giyasov

Authors

Abdumajid Arabov Student Tashkent State Agrarian University
Foziljon Saitkulov Tashkent State Agrarian University
Akbar Abdinazarov Tashkent State Agrarian University
Kuchkar Giyasov Tashkent State Agrarian University

Keywords:

6-Aminopurine; Collagen hydrogel; Biodegradable biomaterial; Tissue regeneration; Controlled release; Wound healing; Extracellular matrix; Bioactive hydrogel.

Abstract

This study investigates the regenerative-stimulating role of 6-aminopurine incorporated into a biodegradable collagen–hydrogel system designed for wound healing applications. Collagen, as a natural extracellular matrix component, provides biocompatibility, biodegradability, and structural support for cell attachment and proliferation. The integration of 6-aminopurine into the hydrogel matrix enables controlled local delivery of the bioactive compound, enhancing cellular activity and tissue regeneration processes. Physicochemical characterization of the collagen–hydrogel system included evaluation of swelling behavior, degradation rate, mechanical stability, and drug release kinetics. Biological assessments demonstrated accelerated epithelialization, improved granulation tissue formation, and enhanced collagen organization in treated wounds compared to control groups. The biodegradable nature of the matrix allows gradual resorption without the need for removal, minimizing secondary tissue damage. The findings suggest that 6-aminopurine–loaded collagen hydrogels represent a promising biomaterial platform for regenerative medicine and advanced wound therapy.

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