RISK FACTORS AND CLINICAL-PROGNOSTIC FEATURES OF THE COURSE OF HYPERTENSIVE DISEASE IN PERSONS AGED 45–59 YEARS

Sotvoldiev Abdulaziz

Authors

Sotvoldiev Abdulaziz Fergana Medical Institute of Public Health

Keywords:

hypertensive disease, arterial hypertension, risk factors, persons aged 45–59 years, cardiovascular risk, target organs, obesity, dyslipidemia, prevention.

Abstract

The article discusses risk factors and features of the course of hypertensive disease in persons aged 45–59 years. It is shown that in this age group, the disease most often develops against the background of a combination of abdominal obesity, physical inactivity, smoking, dyslipidemia, excessive salt intake, chronic stress, and hereditary predisposition. It is noted that hypertensive disease in middle-aged patients often has a minimally symptomatic course, is accompanied by high variability of blood pressure, and is associated with insufficient adherence to treatment. Particular attention is paid to early target-organ damage, including left ventricular hypertrophy, vascular stiffness, microalbuminuria, and decreased renal function. It is concluded that early diagnosis, regular blood pressure monitoring, correction of risk factors, and timely prescription of antihypertensive therapy are necessary.

References

World Health Organization. Hypertension: Fact sheet. Geneva: WHO; 2025. Available at: https://www.who.int/news-room/fact-sheets/detail/hypertension. Accessed: 13.05.2026.

Mancia G., Kreutz R., Brunström M. et al. 2023 ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension. Journal of Hypertension. 2023;41(12):1874–2071. DOI: 10.1097/HJH.0000000000003480.

Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018;39(33):3021–3104. DOI: 10.1093/eurheartj/ehy339.

World Health Organization. Global Report on Hypertension: The Race Against a Silent Killer. Geneva: World Health Organization; 2023. 276 p.

Kario K. The WHO Global report 2023 on hypertension warning the emerging hypertension burden in globe and its treatment strategy. Hypertension Research. 2024;47:1099–1102. DOI: 10.1038/s41440-024-01622-w.

European Society of Cardiology. 2024 ESC Guidelines for the Management of Elevated Blood Pressure and Hypertension. 2024. Available at: https://www.escardio.org/guidelines/clinical-practice-guidelines/all-esc-practice-guidelines/elevated-blood-pressure-and-hypertension/. Accessed: 13.05.2026.

Carey R. M., Muntner P., Bosworth H. B., Whelton P. K. Prevention and control of hypertension: JACC Health Promotion Series. Journal of the American College of Cardiology. 2018;72(11):1278–1293. DOI: 10.1016/j.jacc.2018.07.008.

NCD Risk Factor Collaboration. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies. The Lancet. 2021;398(10304):957–980. DOI: 10.1016/S0140-6736(21)01330-1.

Oparil S., Acelajado M. C., Bakris G. L. et al. Hypertension. Nature Reviews Disease Primers. 2018;4:Article 18014. DOI: 10.1038/nrdp.2018.14.

Whelton P. K., Carey R. M., Aronow W. S. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension. 2018;71(6):e13–e115. DOI: 10.1161/HYP.0000000000000065.

Mills K. T., Stefanescu A., He J. The global epidemiology of hypertension. Nature Reviews Nephrology. 2020;16(4):223–237. DOI: 10.1038/s41581-019-0244-2.

Unger T., Borghi C., Charchar F. et al. 2020 International Society of Hypertension Global Hypertension Practice Guidelines. Hypertension. 2020;75(6):1334–1357. DOI: 10.1161/HYPERTENSIONAHA.120.15026.

Jamoldinovich, A. I. THE RELATIONSHIP BETWEEN ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK IN CHRONIC HEART FAILURE.

Шадиева, Д. К., Холматов, С., & Абдуллаева, М. СЕМАНТИКА В СТРУКТУРЕ СЛОВА И ТЕКСТА ЛИНГВОКОММУНИКАТИВНЫЙ АСПЕКТ. Zbiór artykułów naukowych recenzowanych., 22.