MOLECULAR AND BIOCHEMICAL FOUNDATIONS OF FERMENTOPATHIES: A COMPARATIVE ANALYSIS OF STUDIES BY UZBEKISTANI AND INTERNATIONAL SCIENTISTS

Fozilova Gavharoy Erkinjonovna; Raxmatullo Sheraliyev Jo’raboy o’g’li

Authors

Fozilova Gavharoy Erkinjonovna Assistant, Department of Biological Chemistry, Andijan State Medical Institute
Raxmatullo Sheraliyev Jo’raboy o’g’li Second-year student, Faculty of Pediatrics, Andijan State Medical Institute

Keywords:

Fermentopathy, metabolic block, molecular medicine, Archibald Garrod, Ye.S. Severin, R.A. Sobirova, A.V. Abrorov, phenylketonuria (PKU), glycogen storage diseases, cholelithiasis, allosteric regulation, oxidative stress, bioenergetics, Nelson-Cox concept, clinical biochemistry.

Abstract

This article analyzes the molecular and biochemical foundations of fermentopathies through the prism of the scientific views of international and local scholars. The study examines the historical and scientific hierarchy from Sir Archibald Garrod’s theory of the “metabolic block” to the modern Nelson-Cox and Severin concepts. The contribution of representatives of the Uzbek school of biochemistry, R.A. Sobirova and A.V. Abrorov, to the regional and clinical study of enzymatic processes is also highlighted. Using phenylketonuria, glycogen storage diseases, and gallstone disease as examples, the article provides a detailed analysis of the pathochemical mechanisms of fermentopathies and puts forward personal conclusions and practical recommendations.

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