STAGE-SPECIFIC EPIGENETIC REPROGRAMMING AND TRANSCRIPTION FACTOR DYNAMICS DURING HUMAN SOMATIC TISSUE ONTOGENESIS: AN INTEGRATED CHROMATIN ACCESSIBILITY AND RNA-SEQUENCING STUDY

Nurmetova Gulnoza Qaxramonovna

Authors

Nurmetova Gulnoza Qaxramonovna Asia International University

Keywords:

ontogenesis, epigenetic reprogramming, chromatin accessibility, ATAC-seq, transcription factor networks, cell differentiation, somatic development, SCENIC+, super-enhancers, developmental biology.

Abstract

Background: Ontogenesis—the complete developmental trajectory of an organism from fertilisation through cellular differentiation to tissue maturation—is orchestrated by tightly regulated waves of epigenetic reprogramming and transcription factor (TF) network reconfigurations. While individual developmental events have been characterised in model organisms, the integrated landscape of chromatin accessibility changes and their coupled transcriptional outputs across multiple human somatic tissue lineages during ontogenesis has not been systematically mapped in a single comparative study framework.

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