EARLY STRUCTURAL AND FUNCTIONAL CHANGES OF THE MYOCARDIUM IN PATIENTS WITH METABOLIC SYNDROME: A CLINICO-MORPHOLOGICAL ANALYSIS

Madraximova Nigoraxon Ravshanbek kizi

Authors

Madraximova Nigoraxon Ravshanbek kizi Fergana medical institute of public health

Keywords:

metabolic syndrome, myocardium, insulin resistance, diastolic dysfunction, lipotoxicity, oxidative stress, cardiomyopathy

Abstract

This study aimed to evaluate early structural and functional myocardial changes in patients with metabolic syndrome. A clinico-morphological approach was applied, including anthropometric, biochemical, and echocardiographic assessments[1,2,3]. Insulin resistance was evaluated using the HOMA-IR index. The results demonstrated early diastolic dysfunction, mitochondrial impairment, and microvascular disturbances, contributing to fibrotic changes in the myocardium. These findings highlight the importance of early diagnosis and pathogenetic treatment to prevent progression to heart failure.

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