CORRELATION BETWEEN CARDIOVASCULAR DISEASES AND PERIODONTITIS

Jaloliddinov Sherzodbek Ikromjon ugli

Authors

Jaloliddinov Sherzodbek Ikromjon ugli Fergana medical institute of public health

Keywords:

Periodontitis, cardiovascular diseases, inflammation, atherosclerosis, endothelial dysfunction, periodontal infection, C-reactive protein, systemic inflammation.

Abstract

Recent advances in biomedical research have established a substantial association between periodontitis and cardiovascular diseases (CVDs) [1,2]. Periodontitis, recognized as a chronic inflammatory condition affecting the supporting tissues of the teeth, has been increasingly implicated in the development of systemic inflammatory responses that adversely influence cardiovascular health [3,4].

Accumulating clinical evidence suggests that individuals with severe periodontal disease frequently exhibit significantly elevated serum levels of C-reactive protein (CRP), often reaching two- to three-fold higher concentrations compared with healthy subjects [5,6]. Elevated CRP has been widely acknowledged as an independent predictor of atherosclerotic progression and adverse coronary events [4].

Moreover, inflammatory mediators and bacterial endotoxins originating from periodontal lesions may disseminate through systemic circulation, thereby contributing to endothelial dysfunction and promoting atherogenesis [7,8]. Periodontal pathogens have also been associated with transient bacteremia, platelet activation, and thrombotic processes, further supporting the biological relationship between oral and cardiovascular diseases [12].

References

Джалолиддинов, Ш. И. (2025). Морфология и варианты формы желудка у человека в норме и при патологических состояниях. Canada-scientific review of the problems and prospects of modern science and education, 1(10), 14-17.

Jaloliddinov, S. I. (2025). Perforated ulcer of the stomach and duodenum: Clinical, diagnostic, and surgical aspects (pp. 601–603).

Ikromovich, J. S. (2025). Morphology and variants of the stomach shape in humans in normal and pathological conditions. Journal of innovations in scientific and educational research, 8(12), 79-81.

Джурабаев А. А., Мамасаидов Ж. Т. Чақалоқларда некротик энтероколитда юзага келадиган морфометрик кўрсатичларни ўзига хослиги //Medical journal of Uzbekistan. – 2025. – Т. 1. – №. 4. – С. 78-83. https://doi.org/10.64156/mju.8301

A.A. Djurabayev, J.T.Mamasaidov. Immunohistochemical Characteristics of Processes Occurring in Necrotizing Enterocolitis in Neonates. American Journal of Medicine and Medical Sciences. 2025,15(10):3421-3425. DOI:10.5923/j.ajmms.20251510.30

Мамасаидов Ж.Т., Джурабаев А.А. и Эшбаев Э.А. 2025. Некротик энтероколитда ингичка ичак шиллиқ қаватининг патоморфологияси. Журнал гуманитарных и естественных наук. 1, 17 (янв. 2025), 200–205.

Madraximova, N. R. (2023). Intercorrelation of the size of the eye slit and the anthropometric parameters of the organism. World Bulletin of Public Health, 29, 27-29.

Мадрахимова, Н., & Марасулова, М. (2024). Интерпретация понятия «здоровье» при изучении дисциплины «педагогика» студентами медицинского вуза. Innovative developments and research in education, 3(28), 408-410.

Rahmatjonovna, I. N. (2024). Fast foods are the potential of human health. Ethiopian International Journal of Multidisciplinary Research, 11(05), 365-369.

Рахматжоновна, И. Н. Алиментарного ожирение и репродуктивное здоровье женшин в современном аспекте физической реабилитации. O'zbekiston harbiy tibbiyoti, 4(4), 368-370.

Isaqova, N. (2024). Microscopic examination of sputum. Развитие и инновации в науке, 3(6), 63-66.

Исакова, Н., & Усмонова, Г. (2024, June). Лабараторная диагностика трихомониза. In международная конференция академических наук (Vol. 3, No. 6, pp. 59-65).

Raxmatjonovna, I. N. (2024). Labaratory diagnostics of trichomonisis disease. Ethiopian International Journal of Multidisciplinary Research, 11(05), 496-499.

Raxmatjonovna, I. N. (2023). The problem of acceleration of children's development (literature review). International Multidisciplinary Journal for Research & Development. Volume10, (12), 160-164.

Jamoldinovich, A. I. The relationship between endothelial dysfunction and cardiovascular risk in chronic heart failure.

Jalolidinovna, I. Z. (2022). Hirudotherapy of Migraines-Diseases of Unknown Etiology. Central Asian Journal of Medical and Natural Science, 3(5), 1-4.

Ибрагимова, З. Ж., & Хомидчонова, Ш. Х. (2022). Роль почек в регулировании артериального давления. Экономика и социум, (2-2 (93)), 630-633.

Tishabaeva, N. A., Ibragimova, Z. J., & Mirzajonova, S. A. (2022). Iron deficiency anemia as an actual problem in medical practice. Theoretical & applied science Учредители: Теоретическая и прикладная наука,(4), 653-656.

Джалолиддинов, Ш. И. (2025). Морфология и варианты формы желудка у человека в норме и при патологических состояниях. Canada-scientific review of the problems and prospects of modern science and education, 1(10), 14-17.

Jaloliddinov, S. I., & qizi Rustamova, J. N. (2025). New approaches to the treatment of type 1 and type 2 diabetes mellitus: a 2025 perspective. So ‘ngi ilmiy tadqiqotlar nazariyasi, 9(12), 1-5.

Salohiddin, M., & Sherzodbek, J. (2025). Surunkali gastrit profilaktikasi: zamonaviy yondashuvlar va muammolar. FARS International Journal of Education, Social Science & Humanities., 13(12), 246-250.

Salohiddin, M., & Sherzodbek, J. (2026). Stomatologik implantologiyada prf va sintetik suyak transplantatlari yordamida suyak regeneratsiyasining qiyosiy morfologik baholanishi. American journal of applied medical science, 4(2), 123-127.

Ikromovich, J. S. (2025). Oshqozonning saraton oldi kasalliklari va oshqozon saratoni. Pedagog, 8(11), 265-268.

Ikromjon o‘g‘li, J. S. (2025). Minimal invaziv jarrohlikning rivojlanishi va istiqbollari–laparaskopik va robot yordamida jarrohlik amaliyotlari. Ta'lim innovatsiyasi va integratsiyasi, 59(1), 372-375.

Madaminov, S. M. (2025). Interdisciplinary Pedagogy: Integrated Teaching Anatomy With Diverse Disciplines. Shokh library.