OPTIMIZATION OF COMPREHENSIVE TREATMENT FOR TOTAL AND SUBTOTAL EPISPADIAS IN CHILDREN
Keywords:
Epispadias, total epispadias, subtotal epispadias, children, surgical treatment, orthoneourethroplasty, urinary incontinence, sphincteroplasty, bladder exstrophy, pediatric urology.Abstract
The aim of this study was to improve treatment outcomes in children with total and subtotal epispadias by optimizing surgical techniques. A retrospective analysis was performed on 44 out of 71 patients treated between 1998 and 2024 at the Department of Pediatric Surgery of Tashkent State Medical University and the Republican Scientific and Practical Center for Minimally Invasive and Endoscopic Pediatric Surgery. The patients were aged 1 to 11 years. In 79.5% of cases, penile length was reduced twofold compared to age norms, and in 9.0% it was reduced by 2.5 times; all patients had penile torsion and complete urinary incontinence. Complete urinary continence was achieved in 45.5% of cases, and partial continence in 18.2%, with overall good and satisfactory outcomes in 63.7% of patients. Although one-stage orthoneourethroplasty allows simultaneous penile straightening and urethral reconstruction, it does not fully eliminate urinary incontinence. Therefore, further improvement of sphincteroplasty and pubic symphysis approximation techniques is recommended.
References
Wadhwa PD, Sandman CA, Garite TJ. The neurobiology of stress in human pregnancy: implications for fetal development. American Journal of Obstetrics and Gynecology. 2001;185(5):S131–S139.
Weinstock M. The long-term behavioural consequences of prenatal stress. Neuroscience & Biobehavioral Reviews. 2008;32(6):1073–1086.
Gluckman PD, Hanson MA. Developmental origins of health and disease: a mechanistic perspective. Pediatric Research. 2004;56(3):311–317.
Moisiadis VG, Matthews SG. Glucocorticoids and fetal programming. Nature Reviews Endocrinology. 2014;10(7):391–402.
Glover V. Maternal depression, anxiety and stress during pregnancy and child outcome. Best Practice & Research Clinical Obstetrics and Gynaecology. 2014;28(1):25–35.
Sadler TW. Langman’s Medical Embryology. 14th ed. Philadelphia: Wolters Kluwer; 2019.






Azerbaijan
Türkiye
Uzbekistan
Kazakhstan
Turkmenistan
Kyrgyzstan
Republic of Korea
Japan
India
United States of America
Kosovo