THE ROLE OF THE DRUG VIFERON® IN THE REGULATION OF APOPTOSIS AND ITS EFFECTIVENESS

Authors

  • Makhpieva Guldonakhon Kabiljanovna, Ulugbekov Mirzo Ulugbek Oybek ugli Department of Pediatrics, Faculty of Medicine, ASMI

Keywords:

immunity, apoptosis, hyperthermia, interferon, viferon

Abstract

The end of the 20th century was marked by advances in biology and medicine, including theoretical immunology, which made it possible to take a new look at the etiopathogenesis of a number of diseases. In particular, this refers to changes in the understanding of innate immunity, the discovery of the interferon system, the identification of immunoregulatory cells and subpopulations of lymphocytes producing opposing cytokines, as well as their role in autoimmune pathology.

References

Mansky, V. K. (2007). Cell death pathways and their biological significance. Cytology, 49(11), 909–915.

Kerr, J. F., Wyllie, A. H., & Currie, A. R. (1972). Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26(4), 239–257.

Varga, O. Y., & Ryabkov, V. A. (2006). Apoptosis: Concept, mechanisms of implementation, significance. Human Ecology, 7, 28–32.

Fomchenko, N. E., & Voropaev, E. V. (2013). Biological aspects of apoptosis (literature review). Health and Ecology Issues, 1(35), 39–45.

Grigoryev, M. Yu. (2003). Apoptosis in normal and pathology. Medical Academic Journal, 3(3), 3–11.

Moskaleva, E. Yu., & Severin, S. E. (2006). Possible mechanisms of cell adaptation to damage inducing programmed death. Connection with pathology. Pathological Physiology and Experimental Therapy, 2, 2–16.

Holoch, P. A., & Griffith, T. S. (2009). TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies. European Journal of Pharmacology, 625(1–3), 63–72.

Chervyakova, N. V. (2004). Fas/Fas ligand: Markers of apoptosis. Laboratory, 2, 7–9.

Khaitov, R. M., Pinegin, B. V., & Yarilin, A. A. (2009). Clinical immunology manual: Diagnosis of immune system diseases. Moscow: GEOTAR-Media.

Crouse, J., Bedenikovic, G., Wiesel, M., et al. (2014). Type I interferons protect T cells against NK cell attack mediated by the activating receptor NCR1. Immunity, 40(6), 961–973.

Crouse, J., Xu, H. C., Lang, P. A., & Oxenius, A. (2015). NK cells regulating T cell responses: Mechanisms and outcome. Trends in Immunology, 36(1), 49–58.

Yarilin, A. A., Nikonova, N. F., Yarilina, A. A., et al. (2000). Apoptosis, its role in pathology and importance of its assessment in clinical immunological examination of patients (review). Medical Immunology, 2(1), 7–16.

MacMicking, J. D. (2012). Interferon-inducible effector mechanisms in cell-autonomous immunity. Nature Reviews Immunology, 12(5), 367–382.

De Weerd, N. A., Samarajiwa, S. A., & Hertzog, P. J. (2007). Type I interferon receptors: Biochemistry and biological functions. Journal of Biological Chemistry, 282(28), 20053–20057.

Isakov, V. A., Arkhipova, E. I., & Isakov, D. V. (2013). Herpesvirus infections in humans: Guide for physicians. St. Petersburg: SpetsLit.

Sokolova, T. M., Uspelyevsky, G. P., Kolodyazhnaya, L. V., et al. (2011). Effects of interferon inducers on the expression of apoptosis-regulating genes in human lymphocytes. Cytokines and Inflammation, 10(2), 75–80.

Kharaeva, Z. F., Ivanova, M. R., Kuzmickaya, E. F., et al. (2010). Indicators of activity of TNF-dependent apoptosis pathways in chronic viral infections with high oncogenic risk. Cytokines and Inflammation, 9(4), 127–128.

Bernardo, A. R., Cosgaya, J. M., Aranda, A., & Jiménez-Lara, A. M. (2013). Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells. Cell Death & Disease, 4, e479.

Meylan, E., & Tschopp, J. (2006). Toll-like receptors and RNA helicases: Two parallel ways to trigger antiviral responses. Molecular Cell, 22(5), 561–569.

Rajasuriar, R., Khoury, G., Kamarulzaman, A., et al. (2013). Persistent immune activation in chronic HIV infection: Do any interventions work? AIDS, 27(8), 1199–1208.

Downloads

Published

2026-04-10

How to Cite

Makhpieva Guldonakhon Kabiljanovna, Ulugbekov Mirzo Ulugbek Oybek ugli. (2026). THE ROLE OF THE DRUG VIFERON® IN THE REGULATION OF APOPTOSIS AND ITS EFFECTIVENESS. Ethiopian International Journal of Multidisciplinary Research, 13(4), 620–625. Retrieved from https://eijmr.org/index.php/eijmr/article/view/6017