MORPHOLOGICAL EFFECTS OF VITAMIN D DEFICIENCY ON BONE TISSUE: OSTEOPOROSIS AND OSTEOMALACIA

Djurayeva Ra’no Xayrulloyevna

MORPHOLOGICAL EFFECTS OF VITAMIN D DEFICIENCY ON BONE TISSUE: OSTEOPOROSIS AND OSTEOMALACIA

Authors

Djurayeva Ra’no Xayrulloyevna Department of Fundamental Medical Sciences of the Asian International University. Bukhara, Uzbekistan.

Keywords:

Vitamin D, calcium-phosphorus metabolism, osteoporosis, osteomalacia, osteoid, trabecula, histology

Abstract

Vitamin D is an important endocrine regulator that controls bone metabolism. Its deficiency leads to disruption of calcium-phosphorus homeostasis, imbalance of osteoblast and osteoclast activity, and disruption of bone microarchitecture. This article analyzes the morphological changes caused by vitamin D deficiency in bone tissue, in particular its role in the pathogenesis of osteoporosis and osteomalacia, at the histological and ultrastructural levels.

References

Holick M.F. Vitamin D Deficiency. NEJM

Rosen C.J. Primer on the Metabolic Bone Diseases

Compston J.E. Osteoporosis. Lancet

Kumar V. Robbins & Cotran Pathologic Basis of Disease

Bikle D.D. Vitamin D and Bone

Peacock M. Calcium Metabolism in Health and Disease

Parfitt A.M. Bone Histomorphometry

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Published

2026-03-20

How to Cite

Djurayeva Ra’no Xayrulloyevna. (2026). MORPHOLOGICAL EFFECTS OF VITAMIN D DEFICIENCY ON BONE TISSUE: OSTEOPOROSIS AND OSTEOMALACIA. Ethiopian International Journal of Multidisciplinary Research, 13(03), 765–767. Retrieved from https://eijmr.org/index.php/eijmr/article/view/5661