EARLY DIAGNOSIS OF PITUITARY DWARFISM AND EVALUATION OF THE EFFECTIVENESS OF GROWTH HORMONE THERAPY

Authors

  • Narzilloyeva Malika Shuhrat kizi Department of Fundamental Medical Sciences of the Asian International University, Bukhara, Uzbekistan

Keywords:

pituitary dwarfism, growth hormone deficiency, IGF-1, growth velocity, bone age, recombinant somatropin, pediatric endocrinology.

Abstract

 Pituitary dwarfism is an endocrine disorder associated with growth hormone deficiency and characterized by significant growth retardation in children. This article analyzes the etiopathogenesis of the disease, principles of early diagnosis, modern laboratory and instrumental diagnostic methods, as well as criteria for evaluating the effectiveness of recombinant growth hormone therapy. Research findings indicate that timely diagnosis and early initiation of treatment significantly improve final adult height and help prevent metabolic complications.

References

Melmed S., Auchus R., Goldfine A. et al. Williams Textbook of Endocrinology. 14th ed. Philadelphia: Elsevier; 2020.

Sperling M.A. Pediatric Endocrinology. 5th ed. Philadelphia: Elsevier; 2021.

Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of growth hormone deficiency in childhood and adolescence. Hormone Research in Paediatrics. 2019.

Rosenfeld R.G., Cohen P. Disorders of growth hormone/insulin-like growth factor secretion and action. Endocrine Reviews. 2018.

Deal C.L., Tony M., Höybye C. et al. Growth hormone therapy in children: safety and efficacy review. Journal of Clinical Endocrinology & Metabolism. 2019.

Grimberg A., DiVall S.A., Polychronakos C. et al. Guidelines for growth hormone therapy in children. Pediatrics. 2016.

Downloads

Published

2026-02-24

How to Cite

Narzilloyeva Malika Shuhrat kizi. (2026). EARLY DIAGNOSIS OF PITUITARY DWARFISM AND EVALUATION OF THE EFFECTIVENESS OF GROWTH HORMONE THERAPY. Ethiopian International Journal of Multidisciplinary Research, 13(2), 1257–1259. Retrieved from https://eijmr.org/index.php/eijmr/article/view/5280