DIAGNOSTIC SPECIFICITIES IN WOMEN WITH ANTIPHOSPHOLIPID SYNDROME
Keywords:
antiphospholipid syndrome, recurrent pregnancy loss, β2-glycoprotein I, D-dimer, hemostasis, Doppler ultrasound, fetoplacental system.Abstract
Antiphospholipid syndrome (APS) is one of the leading immuno-thrombotic causes of recurrent pregnancy loss and pregnancy failure in women of reproductive age. APS is characterized by hypercoagulation, endothelial dysfunction, and disturbances in the fetoplacental system resulting from the production of antiphospholipid antibodies. This article presents a comprehensive analysis of the clinical, laboratory, and instrumental diagnostic criteria of APS, emphasizing the diagnostic value of D-dimer, β2-glycoprotein I antibodies, lupus anticoagulant, and Doppler indices. The findings demonstrate that early and integrated screening significantly improves reproductive outcomes and reduces pregnancy loss.
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