DISCOORDINATION OF ADIPOCYTOKINES AND PRODUCTS OF ADIPOSE TISSUE LIPOLYSIS WITH THE DEVELOPMENT OF INSULIN RESISTANCE IN METABOLIC SYNDROME

Uzbekova N.R.

Authors

Uzbekova N.R. Andijan state medical institute, Andijan, Uzbekistan

Keywords:

leptin, adiponectin, triglyceride, free fatty acids, insulin resistance, metabolic syndrome.

Abstract

The aim of the study was to investigate the possible role of adipocytokines (leptin, adiponectin), triglycerides (TG) and free fatty acids (FFA) in the development of insulin resistance (IR) in patients with metabolic syndrome (MS).

The study included 150 patients with MS (57 men and 93 women). The patients with MS with high HOMA index observed increase in TG, FFA, leptin and decreased adiponectin. In groups of patients with different body mass showed that in individuals with obesity in the development of IR may play a role of increasing concentrations of TG, FFA, and leptin, while in patients without significant obesity - increased levels of TG, FFA and decreased adiponectin. We can assume that leptin, adiponectin, triglycerides and FFA can influence the development of IR, however, their contribution depends on the severity of obesity.

References

Vavilova T.P., Pleten A.P., Mikheev R.K. Biological role of adipokines as markers of pathological conditions [Biologicheskaya rol adipokinov kak markerov patologicheskih sostoyaniy]// Nutrition issues. 2017, T. 86, No. 2. pp. 5-13.

Maramygin D.S., Sitnikov R.V., Sumenkova D.V. Adipokines in the pathogenesis of metabolic syndrome [Adipokiny v patogeneze metabolicheskogo sindroma]// International. scientific magazine "Innovative Science". 2017, No. 4(3). pp. 197-203.

Markova T.N., Mishchenko N.K., Petina D.V. Adipocytokines: a modern view of the definition, classification and role in the body [Adipotsitokiny: sovremennyy vzglyad na definitsiyu, klassifikatsiyu i rol v organizme]// Problems of endocrinology. 2022, 66(1), pp. 73-80.

Nikonova L.V., Tishkovsky S.V., Guminskaya O.V. Metabolic activity of adipose tissue and its role in the formation of insulin resistance [Metabolicheskaya aktivnost jirovoy tkani i yeyo rol v formirovanii insulinorezistentnosti]// Journal of Grodno Medical. University. 2012, No. 1. pp. 172-177.

Titov V.N. Leptin and adiponectin in the pathogenesis of metabolic syndrome [Leptin i adiponektin v patogeneze metabolicheskogo sindroma]// Clinical. medicine. 2014, No. 4. pp. 36-42.

Shevchenko E.A., Potemina T.E., Uspensky A.N. The role of adiponectin and leptin in the development of metabolic syndrome and associated obesity and type II diabetes mellitus [Rol adiponektina i leptina v razvitii metabolicheskogo sindroma i svyazannyh s nim ojireniem i saharnym diabetom II tipa]// Bulletin of Med. Institute "REAVIZ". 2022, No. 1. With. 29-37.

Cao Haiming. Adipocytokines in obesity and metabolic disease. Journal of Endocrinology. 2014. 220(2). pp. T47-T59. doi:10.1530/joe-13-0339.

Conde J., Scotece M., Gómez R. At the crossroad between immunity and metabolism: focus on leptin// Expert. Rev. Clin. Immunol. 2010. N 6(5). pp. 801-808.

Gorden P., Zadeh E. S., Cochran E. Syndromic insulin resistance: models for the therapeutic basis of the metabolic. Syndrome and other targets of insulin resistance// Endocr. Pract. 2013. N 18(5). pp. 763-771.

Mattu HS, Randeva HS Role of adipokines in cardiovascular disease// J. Endocrinol. 2013. N 216(1). pp. 17-36.

Reneau J., Goldblatt M., Gould J., Kindel T., Kastenmeier A., Higgins R., Rengel L. Rosemary, Schoyer K., James R., Obi B., Moosreiner A., Nicholson K., Sahoo D., Kidambi S. Effect of adiposity on tissue-specific adiponectin secretion// PLOS ONE. 2018, N 13(6). doi: 10.1371/journal.pone.0198889.

Stern JH, Rutkowski JM, Scherer PE Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk// Cell Metab. 2016, N 23(5). pp. 770-784. https://doi.org/10.1016/j.cmet. 2016.04.011.