EVALUATING THE ROLE OF GUT MICROBIOTA IN THE CLINICAL AND PATHOGENETIC DEVELOPMENT OF GOUT
Keywords:
Gout; Gut microbiota; Dysbiosis; Hyperuricemia; Purine metabolism; InflammationAbstract
Gout is a metabolic and inflammatory disorder primarily caused by purine metabolism dysfunction and excessive accumulation of uric acid, leading to monosodium urate crystal deposition in joints and soft tissues. Recent evidence has demonstrated that gut microbiota dysbiosis plays a crucial role in the pathogenesis and clinical course of gout. This study aimed to evaluate the relationship between intestinal microbial composition, biochemical parameters, and clinical manifestations of gout. A total of 83 participants, including 35 gout patients and 33 healthy controls, were analyzed using 16S rRNA gene sequencing and metagenomic profiling. The results revealed a significant reduction in microbial diversity in gout patients compared to healthy subjects. Beneficial genera such as Faecalibacterium, Subdoligranulum, and Coprococcus were markedly decreased, while pro-inflammatory bacteria including Bacteroides, Paraprevotella, and Barnesiella were increased. Functional analysis based on KEGG and COG databases showed that gout-associated microbiota exhibited higher gene expression in purine metabolism and inflammatory pathways, but reduced activity in butyrate and allantoin synthesis. These findings indicate that intestinal microbiota dysbiosis contributes to hyperuricemia, immune imbalance, and systemic inflammation in gout patients. Therefore, gut microbiota may serve as a potential diagnostic and therapeutic target for preventing disease progression and improving clinical outcomes in gout management.
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