EARLY DIAGNOSIS AND PREVENTION OF NEUROENDOCRINE COMPLICATIONS FOLLOWING TRAUMATIC BRAIN INJURY IN PRIMARY SCHOOL-AGED CHILDREN

Authors

  • Inomova Gulmirakhon Kakhramonjon kizi, Khalimova Zamira Yusufovna Andijan State Medical Institute, Department of Hospital Therapy and Endocrinology Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y.Kh. Turakulov Uzbekistan, 170100, Andijan, Yu. Atabekov Street, 1

Keywords:

traumatic brain injury, children, neuroendocrine complications, early diagnosis, hypothalamic–pituitary axis, prevention

Abstract

Traumatic brain injury (TBI) in children of primary school age represents a significant medical and social problem due to its potential long-term consequences. In addition to neurological deficits, TBI can lead to neuroendocrine complications caused by damage to the hypothalamic–pituitary axis. These complications may negatively affect growth, metabolism, pubertal development, and psychological well-being. The present study aims to analyze the principles of early diagnosis and prevention of neuroendocrine complications following TBI in primary school-aged children. Early identification of hormonal dysfunction and implementation of preventive strategies are essential for preserving normal physical and cognitive development in pediatric patients.

References

World Health Organization. Neurological disorders: public health challenges. WHO; 2006.

Hawley CA. Epidemiology of traumatic brain injury in children. Arch Dis Child. 2003;88:670–673.

Schneider HJ, et al. Hypopituitarism after traumatic brain injury. Lancet. 2007;369:1461–1470.

Tanriverdi F, et al. Pituitary dysfunction after traumatic brain injury. Endocrine Reviews. 2015;36:305–342.

Salehi F, et al. Hypothalamic injury after TBI. Neurosurgery. 2007;61:108–115.

Agha A, Thompson CJ. High risk of hypopituitarism after TBI. J Clin Endocrinol Metab. 2006;91:2105–2111.

Aimaretti G, et al. GH deficiency after childhood TBI. Clin Endocrinol. 2004;61:514–520.

Bondanelli M, et al. Endocrine disorders after TBI. Eur J Endocrinol. 2005;152:679–691.

Klose M, Feldt-Rasmussen U. Endocrine dysfunction after TBI. Nat Rev Endocrinol. 2018;14:543–558.

Kelly DF, et al. Neurobehavioral outcomes after TBI. J Neurosurg. 2000;93:743–751.

Rutter CE, et al. Diagnostic challenges of post-TBI endocrine disorders. Pediatrics. 2010;126:e1230–e1237.

High WM, et al. Long-term consequences of pediatric TBI. J Head Trauma Rehabil. 2010;25:299–308.

Ghigo E, et al. Consensus guidelines on TBI and pituitary dysfunction. Eur J Endocrinol. 2005;152:679–691.

Maghnie M, et al. Early hormonal replacement after TBI. Horm Res Paediatr. 2012;78:104–114.

Behan LA, et al. Neuroendocrine outcomes after pediatric TBI. Endocrine. 2008;34:17–23.

Downloads

Published

2025-12-19

How to Cite

Inomova Gulmirakhon Kakhramonjon kizi, Khalimova Zamira Yusufovna. (2025). EARLY DIAGNOSIS AND PREVENTION OF NEUROENDOCRINE COMPLICATIONS FOLLOWING TRAUMATIC BRAIN INJURY IN PRIMARY SCHOOL-AGED CHILDREN. Ethiopian International Journal of Multidisciplinary Research, 12(12), 779–783. Retrieved from https://eijmr.org/index.php/eijmr/article/view/4306

Issue

Vol. 12 No. 12 (2025): Volume 12 Issue 12

Section

Articles