ABDOMINAL OBESITY CORRELATION OF C-PEPTIDE AND INSULIN RESISTANCE AMONG YOUNGER POPULATIONS

Abstract

Abdominal obesity (AO) has emerged as a major public health concern and is increasingly recognized as a central driver of chronic low-grade systemic inflammation. This inflammatory state is primarily mediated by insulin resistance and the excessive release of pro-inflammatory factors resulting from the expansion and dysfunction of adipose tissue [1,2]. In this context, visceral adipose tissue is considered a metabolically active organ that plays a pivotal role in linking metabolic dysregulation with cardiovascular disease. Given the growing global prevalence of AO, including among younger populations [3], this condition represents a significant contributor to the burden of comorbid metabolic and cardiovascular disorders. Increasing evidence suggests that alterations in adipokine secretion and signaling are critically involved in the pathogenesis of cardiometabolic diseases and their associated complications [4–6]. Dysregulated adipokine profiles have been shown to promote endothelial dysfunction, chronic inflammation, and metabolic impairment, thereby accelerating disease progression.In our previous studies, we demonstrated significant associations between circulating adipokine levels and coronary artery disease (CAD) [7], arterial hypertension (AH)  as well as hypercholesterolemia, underscoring the systemic impact of adipokine imbalance across multiple organ systems. Despite growing evidence, the role of adipokines in the pathogenesis of comorbid conditions remains poorly elucidated. Therefore, the present study aimed to characterize circulating adipokine profiles in young individuals with comorbid diseases