MORPHOLOGICAL AND MORPHOMETRIC CHANGES IN MAJOR SALIVARY GLANDS AFTER EXPERIMENTAL CHEMOTHERAPY

Khaydarova Nargiza Mukhiddinovna

Authors

Khaydarova Nargiza Mukhiddinovna Assistant of the Department of Surgical Dentistry Bukhara State Medical Institute

Keywords:

chemotherapy, salivary gland, morphology, morphometry, cisplatin

Abstract

his study analyzed the morphological and morphometric changes occurring in the major salivary glands (parotid and submandibular glands) under the influence of experimental chemotherapy. A chemotherapy model was developed using cisplatin in six-month-old white outbred rats, and the resulting changes were assessed using histological and morphometric methods. The findings demonstrated a significant disruption in the secretory function and tissue structure of the salivary glands following chemotherapy. Chemotherapy is a chemical treatment method that involves the use of drugs with cytotoxic effects against malignant tumors. The drugs used in chemotherapy can induce various changes in the salivary glands. Therefore, this study investigated the morphological alterations in the tissue of major salivary glands resulting from chemotherapy for breast cancer.

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