COVID-19: CURRENT CONCEPTS OF PATHOGENESIS AND PATHOPHYSIOLOGY (LITERATURE REVIEW)

Bobokulov Mirvokhid Mirsalimovich

Authors

Bobokulov Mirvokhid Mirsalimovich Bukhara State Medical Institute, Assistant, Department of Phthisiology and Pulmonology

Keywords:

SARS-CoV-2, COVID-19, pathogenesis, pathophysiology, ACE 2 , cytokine storm, immune response, coagulopathy , post-COVID syndrome.

Abstract

Infection caused by the SARS-CoV-2 coronavirus is a multisystem disease with a wide spectrum of manifestations, ranging from asymptomatic carriage to critical illness with multiple organ failure. Pathogenesis is based on the direct cytopathic effect of the virus, mediated by binding to angiotensin -converting enzyme 2 (ACE2 ) , and subsequent hyperactivation of the immune system with the development of a " cytokine storm" and coagulopathy . This review systematizes current data on the key stages of COVID-19 pathogenesis, from viral entry to the pathophysiological basis of long-term complications.

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