ANALYSIS OF MODERN DIAGNOSTIC METHODS FOR THE PROLIFERATIVE TYPE OF CHRONIC RHINOSINUSITIS
Keywords:
chronic rhinosinusitis, proliferative type, endoscopy, CT, MMP9, COX2, MET gene, biomarker, morphology.Abstract
This scientific article analyzes the importance of diagnosing the proliferative type of chronic rhinosinusitis (PTCRS) using modern methods, and evaluates the effectiveness of diagnostic algorithms and molecular-biological approaches. The study examined the interrelationship and diagnostic value of endoscopic, radiological, morphological, and molecular genetic examinations. The proliferative type of chronic rhinosinusitis is considered the initial stage of the polypoid form, and its correct diagnosis is crucial for preventing recurrent inflammatory processes. The study results showed that the proliferative type of rhinosinusitis is characterized by mucosal hyperplasia, increased fibroblast activity, and elevated expression of biomarkers. The integrated use of clinical, endoscopic, and molecular methods based on modern diagnostic systems increases the accuracy of diagnosis by more than 30 percent.
References
Djuraev J.A., Soatov I.O. MET (Tyrosine kinase receptor gene) Gene polymorphism among patients with chronic polyposis rhinosinusitis and chronic rhinosinusitis. Clinical Medicine (Klinicheskaya meditsina), Tashkent Medical Academy Journal, 2023, No. 1, pp. 113-116. ISSN 2181-7812. Tashkent Medical Academy, Tashkent, Uzbekistan.
Djuraev J.A., Soatov I.O., Rakhimjanova G.A., Mardonov Kh.A. Results of clinical and cytomorphological studies conducted to identify various forms of chronic polypous rhinosinusitis. Eurasian Journal of Otorhinolaryngology - Head and Neck Surgery, 2024, Vol. 3, Issue 4, pp. 56-61. Tashkent Medical Academy, Tashkent, Uzbekistan. DOI: https://doi.org/10.57231/j.ejohns.2024.3.4.0010
Juraev Jamolbek Abduqahhorovich, Soatov Ilyosjon Olim o'g'li. Comparative analysis of the rs3918242 MMP9 gene polymorphism frequency in a group of patients with chronic polypous rhinosinusitis. Problems of Biology and Medicine, 2024, No. 4 (155), pp. 73-76. Tashkent Medical Academy, Tashkent, Uzbekistan. ISSN 2181-7812.
Soatov Ilyosjon Olim o'g'li, Djuraev Jamolbek Abdukaharovich. Pathomorphological structure of polypous tissue in patients with chronic polypous rhinosinusitis. Uzbekistan Medical Journal, 2023, Issue 2. pp. 59-64. Tashkent Medical Academy, Tashkent, Uzbekistan.
Soatov Ilyosjon Olim o'g'li. Biomarkers and genotyping in the development of chronic polypous rhinosinusitis. Association of Pulmonologists of Central Asia, 2024, pp. 100-103. Tashkent Medical Academy, Tashkent, Uzbekistan. ISSN: - (Article published in the Bulletin of the Pulmonology Center, https://tbcenter.uz/)
Khasanov U.S., Djuraev J.A., Mardonov Kh.A., Soatov I.O., Khodjaeva D.M., Khakimov R.A. Results of comparative analysis of TLR4 gene rs4986791 polymorphism in the development of nasopharyngeal tonsil hypertrophy. Eurasian Journal of Otorhinolaryngology - Head and Neck Surgery, 2024, Vol. 3, Issue 4, pp. 23-27. Tashkent Medical Academy, Tashkent, Uzbekistan. DOI: https://doi.org/10.57231/j.ejohns.2024.3.4.004
Khasanov U.S., Djuraev J.A., Mardonov Kh.A., Soatov I.O., Khodjaeva D.M., Khakimov R.A. Results of the analysis of MBL2 gene polymorphism in alleles and genotypes during the development of nasopharyngeal tonsil hypertrophy. Eurasian Journal of Otorhinolaryngology - Head and Neck Surgery, 2024, Vol. 3, Issue 4, pp. 17-22.
Khasanov U.S., Soatov I.O., Khodjanov S.Kh., Akhundjanov N.O., Rakhimjanova G.A. Results of the analysis of rs20417 polymorphism prevalence in the COX2 gene among patients with chronic polypous rhinosinusitis and chronic rhinosinusitis and in the control group. American Journal of Medicine and Medical Sciences, 2024, 14 (12): 3149-3153. DOI 10.5923/j.ajmms.20241412.13 Tashkent Medical Academy, Tashkent, Uzbekistan.
