ANTHROPOMETRIC AND MORPHOFUNCTIONAL PARAMETERS OF BONE TISSUE: CLINICAL AND PHARMACOLOGICAL SIGNIFICANCE

Rakhmatova Marhabo Rasulovna

Authors

Rakhmatova Marhabo Rasulovna PhD, Associate Professor, Department of Clinical Pharmacology, Abu Ali ibn Sino Bukhara State Medical Institute

Keywords:

Bone tissue; Anthropometry; Morphofunctional parameters; Bone mineral density; Clinical pharmacology; Personalized therapy; Osteoporosis; Pharmacokinetics; Bone remodeling.

Abstract

Bone tissue is a highly specialized dynamic structure that provides mechanical support, participates in mineral metabolism, and regulates multiple physiological processes. Anthropometric and morphofunctional parameters of bone tissue, such as length, thickness, density, mineral content, and morphological proportions, not only reflect individual characteristics of the organism but also serve as important biomarkers of its functional state. From a clinical and pharmacological perspective, assessment of these parameters is essential for selecting rational preventive and therapeutic strategies. Individual differences in bone density and structure influence the pharmacokinetics and pharmacodynamics of drugs affecting bone metabolism, including calcium, vitamin D, bisphosphonates, and selective estrogen receptor modulators. Comprehensive evaluation of bone tissue morphology and function allows for a deeper understanding of bone remodeling mechanisms and the development of personalized clinical-pharmacological approaches for the prevention and treatment of bone disorders.

References

Axmatovna, Mustafaeva Shargiya, et al. "Peculiarities of the morphophenotype and characteristics of the physical performance of young football players and their relationship with the gaming amplitude." Academicia: an international multidisciplinary research journal 11.2 (2021): 1381-1388.

Rakhmatova M. R., Jalolova V. Z. Methods of Research of Body Composition in Athletes. // Electronic Scientific Journal “Biology and Integrative Medicine”, 2020, pp. 1629.

Bouxsein M. L., Keaveny T. M. A Review on Osteoporosis. JAMA. 2010;303(18):18291836.

Kim H. S., Jeong E. S., Yang M. H., Yang SO. Bone mineral density assessment for research purpose using dual energy Xray absorptiometry. Osteoporos Sarcopenia. 2018;4(3):7985. DOI:10.1016/j.afos.2018.09.003.

Haseltine K. N., Chukir T., Smith P. J., Jacob J. T., Bilezikian J. P., Farooki A. Bone Mineral Density: Clinical Relevance and Quantitative Assessment. J Nucl Med. 2021;62(4):446454. DOI:10.2967/jnumed.120.256180.

Xuan R., Song Y., Baker J. S., Gu Y. The Evaluation of Bone Mineral Density based on Age and Anthropometric Parameters in Southeast Chinese Adults: A CrossSectional Study. Med Sci Monit. 2020;26:e92360317. DOI:10.12659/MSM.923603.

Murat S., Dogruoz Karatekin B., Demirdag F., Kolbasi E. N. Anthropometric and Body Composition Measurements Related to Osteoporosis in Geriatric Population. Medeni Med J. 2021;36(4):294301. DOI:10.4274/MMJ.galenos.2021.32396.

Podkhvatilina A. S., Nikitin I. G., Shchelykalina S. P. Assessment of body composition parameters in patients with osteoporosis. Clinical Nutrition and Metabolism. 2023;4(3):176186. DOI:10.17816/clinutr624192.

HasaniRanjbar S., JafariAdli S., Payab M. et al. Association of Osteoporosis with Anthropometric Measures in a Representative Sample of Iranian Adults: The Iranian Multicenter Osteoporosis Study. Int J Prev Med. 2019;10:157. DOI:10.4103/ijpvm.IJPVM_326_17.

Manzoori H. Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review. Biomedicines. 2024;12(8):1635. DOI:10.3390/biomedicines12081635.

Rakhmatova M.R., Zhalolova V.Z. Yunior va kadet sportsmenlarda tananing kompazitsion tarkibini ŭrganish. // Tibbiyotda yangi kun. - № 2 (30/2). - B. 67- 70

Rakhmatova Markhabo Rasulovna, Zhalolova Vazira Zamirovna . Metody issledovaniya kompozitsionnogo sostava tela u sportsmenov // Biologiya i integrativnaya meditsina. 2020. №4 (44).