THE IMPACT OF TRANSCRANIAL MAGNETIC STIMULATION ON AUTONOMIC DYSFUNCTION IN LUMBAR SPINE DORSOPATHY

Qurbonova Anorabegim Ibrohim kizi

Authors

Qurbonova Anorabegim Ibrohim kizi 2nd-year Master’s Student, Tashkent Medical University

Keywords:

Transcranial magnetic stimulation, lumbar spine dorsopathy, autonomic dysfunction, neuromodulation, rehabilitation, autonomic nervous system, stress hormones, heart rate variability

Abstract

Lumbar spine dorsopathy is a prevalent musculoskeletal condition characterized by restricted mobility, pain syndromes, and autonomic dysfunction. Vegetative symptoms—including heart rate instability, gastrointestinal dysregulation, sleep disturbances, and stress sensitivity—significantly impair patients’ quality of life and complicate rehabilitation efforts. Transcranial magnetic stimulation (TMS), a non-invasive neuromodulation technique, has demonstrated potential in modulating cortical activity, alleviating pain, stabilizing emotional states, and influencing autonomic regulation.

This review article explores the theoretical and clinical foundations for applying TMS in patients with lumbar dorsopathy who present with autonomic dysfunction. It analyzes the neurophysiological mechanisms underlying TMS, its effects on central autonomic networks, and its influence on biomarkers such as stress hormones and heart rate variability. Furthermore, the article discusses the integration of TMS into multidisciplinary rehabilitation protocols and outlines directions for future research.

References

Arora T., Desai N., Kirshblum S., Chen R. Utility of transcranial magnetic stimulation in the assessment of spinal cord injury: Current status and future directions. Frontiers in Rehabilitation Sciences. 2022;3:1005111. https://doi.org/10.3389/fresc.2022.1005111

Mikaël M., et al. Corticomotor control of lumbar erector spinae in postural and voluntary tasks: the influence of transcranial magnetic stimulation current direction. eNeuro. 2024. https://doi.org/10.1523/ENEURO.0454-22.2023

Fan S., Wang W., Zheng X. Repetitive Transcranial Magnetic Stimulation for the Treatment of Spinal Cord Injury: Current Status and Perspective. International Journal of Molecular Sciences. 2023;26(2):825. https://doi.org/10.3390/ijms26020825

Olechowski C., Gener M., Aiyer R., Mischel N. Transcranial magnetic stimulation for the treatment of chronic low back pain: a narrative review. Frontiers in Pain Research. 2023;4:1092158. https://doi.org/10.3389/fpain.2023.1092158

Edwards D.J., Fried P.J., Davila-Pérez P., et al. A Practical Manual for Transcranial Magnetic Stimulation. Springer. 2024. https://link.springer.com/book/10.1007/978-3-031-62304-2

Cabrerizo M., et al. Induced Effects of Transcranial Magnetic Stimulation on the Autonomic Nervous System and the Cardiac Rhythm. The Scientific World Journal. 2014; Article ID 349718. https://doi.org/10.1155/2014/349718

Keriven H., et al. Influence of combined transcranial and peripheral electromagnetic stimulation on the autonomous nerve system on delayed onset muscle soreness in young athletes: a randomized clinical trial. Journal of Translational Medicine. 2025;23:306. https://doi.org/10.1186/s12967-025-06238-3

Ishida F.A., et al. The Effect of Transcranial Magnetic Stimulation (TMS) on Stress Levels, Quality of Sleep, and the Autonomic Nervous System: A Case Study. Advances in Clinical and Translational Research. 2018;1. https://emrespublisher.com/open-access-pdf/a-case-study-the-effect-of-transcranial-magnetic-stimulation-tms-on-stress-levels-quality-of-sleep-and-the-autonomic-nervous-system-100004.pdf

Lefaucheur J.P., et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clinical Neurophysiology. 2020;131(2):474–528. https://doi.org/10.1016/j.clinph.2019.11.002

Nardone R., et al. Transcranial magnetic stimulation and spinal cord injury: a review. Spinal Cord. 2015;53(3):168–177. https://doi.org/10.1038/sc.2014.199