PATIENTS WITH POLLEN-FOOD ALLERGY ENCOUNTERS

Abstract

In sensitized people, the interaction of a specific pollen allergen with a corresponding food allergen activates pollen-food allergy syndrome (PFAS). Although oral symptoms are theost prevalent signs, certain individualsmay also face extra symptoms like nasal congestion, skin reactions, breathing difficulties, or potentially fatal anaphylactic shock. The onset of pollen-food allergy syndrome (PFAS) entails mast cells in the oral mucosa that become sensitized to particular pollen antigens attached to IgE. These mast cells subsequently cross-react with food antigens, initiating a localized type I allergic response upon consuming foods with protein antigens (panallergens) that have structural resemblances to pollen antigens. The distribution of PFAS is affected by local differences in the types and amounts of pollen. Research on per- and polyfluoroalkyl substances (PFAS) is a global effort due to the prevalence of different pollen allergens like alder and grass associated with this condition. This review explores the recent discoveries regarding the pathophysiology, epidemiology, and clinical features of PFAS. We also emphasize important research voids that need to be filled to enhance patient outcomes for individuals impacted by PFAS