ACTIVITY OF TRICARBOXYLIC ACID CYCLE ENZYMES IN THE BLOOD OF WORKERS EXPOSED TO THE PESTICIDE NURELLE

Abstract

 This study presents findings on the effects of the pesticide Nurelle on key biochemical parameters in the blood of individuals occupationally exposed to this compound. Special attention is paid to changes in cholinesterase activity and acetylcholine levels as indicators of neurotoxicity, along [1,2]with a discussion of the potential disruption of mitochondrial tricarboxylic acid (TCA) cycle enzymes. A statistically significant decrease in cholinesterase activity (by 27.4%) and an increase in acetylcholine levels (by 150%) were observed in exposed workers compared to the control group.

These results indicate a pronounced toxic effect of Nurelle on enzymatic systems responsible for both energy metabolism and neural regulation. The study emphasizes the need for regular biochemical monitoring and preventive health measures for workers in pesticide-exposed environments.