METABOLIC ASSOCIATED FATTY LIVER DISEASE (MAFLD)
Keywords:
hepatocyte, steatohepatitis, hepatosis, triglycerides, steatosis, insulin resistance.Abstract
Metabolic Associated Fatty Liver Disease (MAFLD) is a chronic non-infectious condition characterized by structural changes in liver tissue. The primary manifestation of this pathology is the excessive accumulation of fat (mainly triglycerides) in liver cells—hepatocytes. As the disease progresses, inflammation (steatohepatitis), the formation of fibrous tissue, and in severe cases, cirrhosis may develop. In everyday language, MAFLD is [1,2] often referred to as “fatty liver” or hepatic steatosis. Although the disease is usually asymptomatic or mild in its clinical presentation, it is closely associated with metabolic disorders, significantly increasing the risk of cardiovascular complications. This, in turn, negatively affects the patient’s overall health, reducing both life expectancy and quality of life.
References
Клинические рекомендации по диагностике и лечению жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Гепатология, журнал. № 2, 2016. С. 24-42.
Буеверов А.О., Богомолов П.О., Маевская М.В. Патогенетическое лечение неалкогольного стеатогепатита: обоснование, эффективность, безопасность // Терапевтический архив – 2007. – Т. 79. – № (8). – С. 1-4.
Лазебник Л.Б., Радченко В.Г., Голованова Е.В. и др. Неалкогольная жировая болезнь печени: клиника, диагностика, лечение // Экспериментальная и клиническая гастроэнтерология. — М., 2015. — № 7. — С. 85-96.
Mantovani A, Csermely A, Bilson J, et al Association between primary hypothyroidism and metabolic dysfunction-associated steatotic liver disease: an updated meta-analysis Gut Published Online First: 23 May 2024. doi: 10.1136/gutjnl-2024-332491.
Jurabaev A.A., Eshbaev E.A., Mamasaidov Zh.T. - Pathomorphological changes in necrotic enterocolitis of the lateral layer of the intestinal//New Day in Medicine 11(73)2024 964-970
Мамасаидов Ж. Т., Джурабаев А. А., Эркин А. Э. Некротик энтероколитда ингичка ичак шиллиқ қаватининг патоморфологияси //Журнал гуманитарных и естественных наук. – 2024. – №. 17. – С. 200-205.
Isaqova, N. R. (2022). Influence of constipation on anthropometric indicators of children. Science and Innovation, 1(8), 888-892.
Raxmatjonovna, I. N. (2023). Effects of colonic diseases on children’s health. World bulletin of public health, 23, 101-103.
Del Campo JA, Gallego-Durán R, Gallego P, Grande L. Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD). Int J Mol Sci. 2018 Mar 19;19(3) [PMC free article] [PubMed]
Basaranoglu M, Neuschwander-Tetri BA. Nonalcoholic Fatty Liver Disease: Clinical Features and Pathogenesis. Gastroenterol Hepatol (N Y). 2006 Apr;2(4):282-291. [PMC free article] [PubMed]
Lee YH, Cho Y, Lee BW, Park CY, Lee DH, Cha BS, Rhee EJ. Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis. Diabetes Metab J. 2019 Feb;43(1):31-45. [PMC free article] [PubMed]
Azerbaijan
Türkiye
Uzbekistan
Kazakhstan
Turkmenistan
Kyrgyzstan
Republic of Korea
Japan
India
United States of America
Kosovo