GENEXPERT AND MYCOBACTERIUM TUBERCULOSIS
Keywords:
Tuberculosis, transmission rates, tests, GeneXpert, treatment monitoring.Abstract
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), an infectious disease that affects the skin, abdomen, and lungs. Numerous methods can be used to diagnose tuberculosis, including direct sputum smears for microscopy, culture-based testing, serology, and nucleic acid amplification techniques (NAATs). Chest radiography is also crucial for the diagnosis, disease prognosis, and treatment monitoring . Recently, new diagnostic techniques have emerged, including the geneXpert assay and interferon-gamma release assays [3]. In order to successfully eradicate tuberculosis, the right technique must be chosen for precise and rabid detection, which lowers death and transmission rates [4].
References
Palomino, J.C. (2005) Nonconventional and New Methods in the Diagnosis of Tuberculosis: Feasibility and Applicability in the Field. European Respiratory Journal, 26, 339-350.
Banada, P.P. and Koshy, R. (2013) All and D. Detection of Mycobacterium tuberculosis in Blood by Use of the Xpert MTB/RIF Assay. Journal of Clinical Microbiology, 51, 2317-2322.
Dorman, S.E. (2010) New Diagnostic Test for Tuberculosis: Bench, Bedside and Beyond. Clinical Infectious Diseases, 50, S173-S177.
Piatek, S.A., van Cleeff, M., Alexander, H., Coggin, L.W., Rehr, M., van Kampen, S., et al. (2013) GeneXpert for TB Diagnosis: Planned and Purposeful Implementation. Global Health: Science and Practice, 1, 18-23.
Van Rie, A., Fitzgerald, D., Kabuya, G., Van Deun, A., Tabala, M., Jarret, N., et al. (2008) Sputum Smear Microscopy: Evaluation of Impact of Training, Microscopedistribution, and Use of External Quality Assessment. Guidelines for Resource Poor Settings. Journal of Clinical Microbiology, 46, 897-901.
Nour, E.M.M., Saeed, E.M.A., Zaki, A.Z.S.A. and Saeed, E.N.S. (2011) Specificity of Sputum Smear Compare to Culture Diagnosis of Pulmonary Tuberculosis. World Journal of Medical Sciences, 6, 121-125.
Lawn, D.S., Nicol, P.M. (2011) Xpert MTB/RIF Assay: Development, Evaluation and Implementation of a New Rapid Molecular Diagnostic for Tuberculosis Andrifampicin Resistance. Future Microbiology, 6, 1067-1082.
Walusimbi, S., Bwabga, F., De Costa, A., Haile, M., Joba, M. and Hoffner S. (2013) Meta Analysisto Compare the Accuracy of GeneXpert, MODS and the WHO 2007 Algorithm for the Diagnosis of Smear Negative Pulmonary Tuberculosis. BMC Infectious Diseases, 13, Article No. 507.
