TO STUDY THE EFFECT OF SOME NEW CYTISINE DERIVATIVES ON THE COURSE OF ACUTE ALCOHOL INTOXICATION IN WHITE MICE

Latipova Shakhlo Bekdurdievna

Authors

Latipova Shakhlo Bekdurdievna TTA Urganch Branch Assistant at the Department of Pharmacology and Clinical Pharmacology.

Keywords:

Cytisine derivatives, acute alcohol intoxication, white mice, nicotinic acetylcholine receptors, ethanol metabolism, oxidative stress, neuroprotection.

Abstract

This study investigates the effects of novel cytisine derivatives on the course of acute alcohol intoxication in white mice. Cytisine, a nicotinic acetylcholine receptor (nAChR) partial agonist, has shown promise in modulating alcohol-related behaviors. We synthesized and tested three new cytisine derivatives (CD1, CD2, CD3) to assess their impact on ethanol-induced behaviors, blood alcohol levels, and hepatic oxidative stress. Results indicate that CD2 significantly reduces intoxication duration and enhances alcohol metabolism, suggesting potential therapeutic applications. These findings contribute to understanding cytisine-based compounds as candidates for managing acute alcohol intoxication.

References

Shaimardanov RA, Iskandarov S, Yunusov SY. A study of the alkaloids of Thermopsis alterniflora. Chem Nat Compd 1971; 7: 160–4.

Karnieg T, Wang X. Cytisine for smoking cessation. CMAJ. 2018 May 14; 190(19): E596.

Satimov GB, Mamatkhanov AU, Kotenko LD, Madrakhimov ShN, Faizieva SKh et al. A Total Flavonoid Extract from Thermopsis altherniflora: Development of the Production Technology, Creation of a Medicinal Preparation, and Evaluation of Hypolipidemic Activity. Pharm Chem J 2003; 37: 203–6.

Mamatkhanova MA, Sotimov GB, Vinogradova VI, Kotenko LD, Mamatkhanov AU. Development of a technology for obtaining cytisine and flateron from the aerial part of Thermopsis alterniflora. Chem and Chem Tech 2016; 4:40-4.

Azamatov AA, Tursunkhojaeva FM, Rezhepov, Rakhimov ShB. Study of the effect of cytisine derivatives on the course of acute alcohol intoxication. Reports of the Academy of Sciences of the Republic of Uzbekistan 2013;6: 39-1.

Azamatov АА, Rejepov J, Tursunkhodjayeva FM, Rakhimov Sh B, Vinogradova VI. Antixypoxant, anti-narcotic activity and acute toxicity of N-methylcytisine. European science review 2018; 5-6:123-6.

Azamatov АА, Rejepov J, Tursunkhodjayeva FM. Antitoxic effects of two new N-benzyl derivatives of cytisine in acute and chronic alcohol intoxication. European science review 2018;11-12: 46-8.

Litchfield Jr JT, Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. and Exp. Ther. 1949, 96 (2): 99- 13