CATECHOLAMINES EFFECTS ON CARDIOMYOCYTE MITOCHONDRIAL AND OXIDATIVE PHOSPHORYLATION ENZYMES
Keywords:
Сatecholamines, adrenaline, enzymes, beta adrenoreceptors, biogenic aminesAbstract
This review outlines the pharmacological possibilities of catecholamine signaling for the management of socially important disorders like hypertension, Parkinson's disease, and depression. Dopamine, norepinephrine, and epinephrine, the catecholamines, are released as hormones and as neurotransmitters in the nervous system. Prolactostatin, a hormone that is biochemically dopamine, is constantly released by hypothalamic neurons in both sexes. Norepinephrine activates the alpha and beta adrenoreceptors of target cells as the principal mediator released from the postganglionic endings of sympathetic neurons. Norepinephrine is released in little quantities as a hormone in the adrenal medulla, where it serves as a precursor to epinephrine production. Both norepinephrine and epinephrine trigger stress reactions through a generalized sympathetic "fight-or-flight" response, which raises cardiac output, blood pressure, and respiration.It is now crucial in cardiology to determine the mechanisms of adaptation to disturbances seen during hyperactive sympathetic nervous system activity in order to create effective treatments for cardiovascular disease.
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