ASSESSMENT OF MOLECULAR GENETIC RISK FACTORS FOR CHOLELITHIASIS

Abstract

The prevalence of cholelithiasis, its close pathogenetic relationship with metabolic syndrome, the high frequency of surgical intervention, and significant economic losses put this comorbid pathology among the leading problems of modern clinical medicine. Factors associated with metabolic syndrome not only increase the risk of cholelithiasis, but also form the basis of non-drug and drug therapy. Metabolic syndrome often determines the occurrence of three common and potentially life-threatening complications of cholelithiasis: acute cholecystitis, acute cholangitis, and biliary pancreatitis. Therefore, the solution of this problem is associated with the need for early detection of additional risk factors for cholelithiasis, optimization of the early diagnostic and prognostic model of the existing multi-organ pathology in order to reduce the progression of the disease and its complications. The data obtained in recent years on the genome of a person with metabolic syndrome and cholelithiasis make it possible to predict the development of comorbid pathology and fully ensure the effectiveness of primary prevention.