MICROBIAL DYNAMICS AND IMMUNOLOGICAL RESPONSES IN THE LUNGS IN SECONDARY BACTERIAL PNEUMONIA CAUSED BY COVID-19
Keywords:
Bacterial pneumonia, COVID-19, immune response.Abstract
Although it is still poorly understood, secondary bacterial pneumonia (secondary bacterial pneumonia) is linked to substantial morbidity after respiratory virus infection. We compare the pulmonary transcriptome and longterm airway microbiome dynamics of patients who developed secondary bacterial pneumonia to controls who did not in a prospective cohort of 112 critically sick people who were intubated for COVID-19. We discover a substantial correlation with secondary bacterial pneumonia and corticosteroid treatment as well as death. Increased bacterial RNA mass and the predominance of culture-confirmed pathogens, which can be found days before a secondary bacterial pneumonia clinical diagnosis and are commonly also seen in nasal swabs, are characteristics of the pulmonary microbiome in secondary bacterial pneumonia.
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