REVIEWING POLLEN-FOOD ALLERGY SYNDROME IN DETAIL
Keywords:
Pollen-food allergy syndrome, antigen, symptoms, cross-reactionAbstract
The cross-reaction of a particular pollen antigen with the associated food allergen in sensitized individuals results in pollen-food allergy syndrome (PFAS). Usually, only oral symptoms are present; nevertheless, on occasion, rhinitis, skin, and respiratory symptoms, as well as anaphylactic shock, might happen. In PFAS pathogenesis, mast cells attached to pollen antigen-specific IgE dispersed in the oral mucosa cross-react with the food antigen, resulting in a localized type I allergic reaction, when food containing protein antigens (pan-allergens) with high similarity to pollen antigens is consumed. Geographical factors, such as the kind and quantity of pollen in the region, influence the occurrence of PFAS. Because so many different pollen allergens, including alder and grass, are linked to the disease, PFAS is present around the world. The current state of research on the pathophysiology, epidemiology, and clinical aspects of per- and polyfluoroalkyl substances (PFAS) is reviewed in this study. We list the unmet research needs that need to be filled in order to help patients with PFAS have better outcomes.
References
M. Ebisawa, k. Ito, t. Fujisawa, committee for japanese pediatric guideline for food allergy, the japanese society of pediatric allergy and clinical immunology, the japanese society of allergology japanese guidelines for food allergy 2020 allergol int, 69 (2020), pp. 370-386
Y. Kondo, a. Urisu oral allergy syndrome allergol int, 58 (2009), pp. 485-491
D. Mittag, s. Vieths, l. Vogel, w.m. becker, h.p. rihs, a. Helbling, et al. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens J allergy clin immunol, 113 (2004), pp. 148-154
P.l. amlot, d.m. kemeny, c. Zachary, p. Parkes, m.h. lessof oral allergy syndrome (oas): symptoms of ige-mediated hypersensitivity to foods Clin allergy, 17 (1987), pp. 33-42
G. Carlson, c. Coop pollen food allergy syndrome (pfas): a review of current available literature Ann allergy asthma immunol, 123 (2019), pp. 359-365
M. Vanek-krebitz, k. Hoffmann-sommergruber, m. Laimer da camara machado, m. Susani, c. Ebner, d. Kraft, et al. Cloning and sequencing of mal d 1, the major allergen from apple (malus domestica), and its immunological relationship to bet v 1, the major birch pollen allergen Biochem biophys res commun, 214 (1995), pp. 538-551
M.h. shamji, r. Valenta, t. Jardetzky, v. Verhasselt, s.r. durham, p.a. würtzen,The role of allergen-specific ige, igg and iga in allergic disease Allergy, 76 (2021), pp. 3627-3641
T.e. velez, p.j. bryce, k.e. hulse Mast cell interactions and crosstalk in regulating allergic inflammation Curr allergy asthma rep, 18 (2018), p. 30
