DETERMINATION OF INFORMATIVITY OF XYLITOL AND GLYCEROL PREPARATIONS FOR DETECTION OF INTRALABYRINTHINE HYDROPS

Nasretdinova M.T., Normirova N.N.  Normuradov N.A., Xusanova D.A

Authors

Nasretdinova M.T., Normirova N.N. Normuradov N.A., Xusanova D.A Samarkand State Medical University

Keywords:

intralabyrinthine hydrops, xylitol, glycerol, labyrinth, glucose tolerance test

Abstract

The issue of interpretation of the results of dehydration tests, the frequency of detection of intralabyrinthine hydrops and the percentage of concordance of data when using different drugs remains controversial. The aim of the present work was to determine the informativeness of the dehydrating ability of glycerol, furosemide, glucose and xylitol on the basis of changes (increase or decrease) in auditory thresholds, confirmed by a reliable change in serum osmolality after their administration. The aim of the study was to determine the informativeness of the preparations used to detect intralabyrinthine hydrops on the basis of audiologic examination. 96 individuals aged 23 to 42 years (men - 41, women - 55) suffering from Meniere's disease for 3-15 years were examined. All patients underwent glycerol test (in doses of 0.6 and 1.5 g/kg of weight). Other tests were performed before (5-7 days before) or after (5-7 days after) glycerol administration. In each case, the indication for the samples was the need to diagnose cochlear hydrops or hydrops of the non-auditory part of the labyrinth. The standard glucose-tolerant test was used to detect possible disorders of carbohydrate metabolism. Furosemide was administered intramuscularly at a dose of 20 mg once a day. The presence of disadvantages in each of the used drugs led to the necessity of approbation of a new remedy - xylitol. The examination of 96 patients showed that out of 4 studied preparations for diagnostics of intralabyrinthine hydrops the informativity of xylitol and glycerol considerably exceeds that of glucose and furosemide, but the use of the latter is justified in those cases when the above mentioned preparations are absent or cannot be used due to contraindications. The informativity of xylitol and glycerol is significantly higher than that of furosemide and glucose.

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