M1 AND M2 MACROPHAGES ARE PREDICTORS OF ADVERSE OUTCOMES IN HUMAN ATHEROSCLEROSIS

Xakimova I. T.

Authors

Xakimova I. T. Phthisiology and pulmonology, microbiology, virology and immunology department: Assistant Andijan State Medical Institute. Uzbekistan.

Keywords:

Ischemic heart disease, inflammation, atherosclerosis, macrophages.

Abstract

Macrophages play a central role in the development of atherosclerotic cardiovascular diseases (ACCDS), which include coronary heart disease, peripheral artery disease, cerebrovascular disease, and aortic atherosclerosis. In each vascular bed, macrophages help maintain a local inflammatory response, promote plaque development, and promote thrombosis. This central role, combined with their plasticity, makes macrophages attractive therapeutic targets for stopping the development and stabilizing existing atherosclerosis. In the context of ACCSS, classically activated M1 macrophages1 initiate and maintain inflammation, and alternatively activated M2 macrophages resolve inflammation. Atherosclerotic cardiovascular diseases (ACCDS) are the leading cause of morbidity and mortality worldwide [1]. Vascular inflammation, even after a significant reduction in cholesterol levels, is considered an important risk factor for recurrent atherothrombotic events, and macrophages are a likely contributor to the risk of residual inflammation.

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