KLOTHO PROTEIN IN THE BLOOD OF MEN WITH TYPE 2 DIABETES
PDF

Keywords

Klotho protein, diabetes mellitus, cardiovascular diseases, risk factors.

How to Cite

Shokirova Gulnozakhon Kadirjanovna. (2025). KLOTHO PROTEIN IN THE BLOOD OF MEN WITH TYPE 2 DIABETES. Ethiopian International Multidisciplinary Research Conferences, 54–56. Retrieved from https://eijmr.org/conferences/index.php/eimrc/article/view/376

Abstract

The Klotho protein content in men with diabetes was significantly lower than in individuals without diabetes (374 [117; 500] and 515 [315; 1009] pg/ml, respectively, p < 0.0001). In men with diabetes, in whom the glomerular filtration rate is less than 60 ml/min/1.73 cm2, the Klotho protein concentration was 4 times lower than in the comparison group (104 [93; 118] and 413 [147; 535] pg/ml, respectively, p = 0.014). In the presence of diabetes, an inverse correlation was observed between Klotho protein content and abdominal obesity (waist to hip ratio) (−0.329; p = 0.047), but multivariate analysis only revealed a tendency toward a negative association of these parameters (−0.385, p = 0.078).

PDF

References

Emerging Risk Factors Collaboration, Sarwar N., Gao P., Seshasai S.R., Gobin R., Kaptoge S., di Angelantonio E., Ingelsson E., Lawlor D.A., Selvin E., Stampfer M., Stehouwer C.D. , Lewington S., Pennells L., Thompson A., Sattar N., White I.R., Ray K.K., Danesh J. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet. 2010; 375 (9733): 2215–2222. doi: 10.1016/S0140-6736(10)60484-9

Diabetes. Access mode: https://www.who.int/ru/news-room/fact-sheets/detail/diabetes.

Kuro-o M., Matsumura Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Ii-da T., Nishikawa S., Nagai R., Nabeshima Y.I. Mutation of the mouse Klotho gene leads to a resembling aging syndrome. Nature. 2017; 390 (6655); 45–51. doi: 10.1038/36285

Hasannejad M., Samsamshariat S.Z., Esmaili A., Jahanian-Najafabadi A. Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells. Res. Pharm. Sci. 2019; 14 (4): 369–377. doi: 10.4103/1735-5362.263627

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.