IN SILICO ANALYSIS OF THE PHYSICOCHEMICAL PROPERTIES OF SOME PROTEINS IN THE HUMAN BODY
Keywords:
in silico analysis, human proteins, physicochemical properties, amino acid composition, protein stability, GRAVY index, isoelectric point, bioinformatics, protein structure, molecular analysisAbstract
The study presents an in silico investigation of the physicochemical properties of selected human proteins with the aim of understanding their structural stability and functional potential. Modern bioinformatics tools and databases were employed to analyze key parameters, including molecular weight, theoretical isoelectric point (pI), amino acid composition, instability index, aliphatic index, and grand average of hydropathicity (GRAVY). The obtained results demonstrate that variations in amino acid sequences significantly influence protein stability, solubility, and interaction capacity. In particular, proteins with lower instability index values were predicted to be more stable under physiological conditions, while GRAVY values provided insight into their hydrophilic or hydrophobic nature. The study highlights the importance of computational approaches in protein characterization, allowing rapid and cost-effective prediction of biochemical properties without the need for laboratory experiments. The findings contribute to a deeper understanding of protein behavior in the human body and may support further research in molecular biology, drug design, and biomedical applications.
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