IMMUNE MECHANISMS OF SUBCLINICAL MYOCARDIAL INJURY IN ARTERIAL HYPERTENSION: THE ROLE OF CYTOKINES AND REMODELING FACTORS
Keywords:
Arterial hypertension, subclinical myocardial injury, immunoinflammation, cytokines, complement system, angiogenesis, fibrosisAbstract
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, with arterial hypertension being one of the major modifiable risk factors for ischemic heart disease. In recent years, increasing attention has been paid to subclinical myocardial injury, which precedes the clinical manifestation of coronary pathology. Immunoinflammatory mechanisms, including cytokine imbalance, complement activation, and myocardial remodeling, play a key role in these processes; however, their prognostic significance remains insufficiently studied.
References
Libby P. Inflammation in atherosclerosis: from pathophysiology to practice // Journal of the American College of Cardiology. – 2021.
Ridker P.M. Anti-inflammatory therapy and cardiovascular risk reduction: IL-6 pathway insights // New England Journal of Medicine. – 2020.
Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease // New England Journal of Medicine. – 2021.
Ricklin D., Reis E.S., Mastellos D.C. Complement system in inflammation and disease // Nature Reviews Immunology. – 2022.
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