MEDICATION-RELATED IATROGENESIS AND ADVERSE DRUG EFFECTS IN PREGNANT WOMEN: RISKS, PATTERNS, AND CLINICAL IMPLICATIONS

Abstract

Medication-related iatrogenesis is an increasingly recognized contributor to maternal morbidity and adverse pregnancy outcomes. Physiological changes during pregnancy alter pharmacokinetics and pharmacodynamics, increasing the risk of adverse drug reactions. This study aimed to evaluate the prevalence, types, and consequences of drug-related iatrogenic events in pregnant women, identify high-risk medications, and assess clinical outcomes. A retrospective review of 2018–2024 maternal hospital records was conducted, analyzing cases of maternal morbidity and mortality linked to drug therapy. Findings indicate that the most frequent adverse effects were hepatotoxicity, allergic reactions, hypotension, and preterm labor. High-risk medications included antibiotics, NSAIDs, antihypertensives, anticoagulants, and certain anti-epileptic drugs. Early recognition, careful prescription practices, and monitoring are essential to minimize harm. Multidisciplinary management and adherence to evidence-based guidelines significantly reduce maternal and fetal complications.