PRIMARY AND SECONDARY PREVENTION OF GOUT IN METABOLIC SYNDROME

Abstract

Gout is a chronic metabolic disease that is closely associated with metabolic syndrome, sharing common pathogenic mechanisms such as hyperuricemia, insulin resistance, obesity, and dyslipidemia. The coexistence of gout and metabolic syndrome significantly increases the risk of cardiovascular and renal complications, emphasizing the need for effective preventive strategies. This study analyzes the role of primary and secondary prevention of gout in patients with metabolic syndrome. Primary prevention focuses on lifestyle modification, dietary regulation, weight reduction, and control of metabolic risk factors to reduce serum uric acid levels and prevent disease onset. Secondary prevention aims to prevent recurrent gout attacks and disease progression through long-term urate-lowering therapy, anti-inflammatory treatment, and comprehensive management of metabolic syndrome components. The findings highlight that an integrated preventive approach combining lifestyle interventions and pharmacological therapy is essential for reducing the burden of gout, improving quality of life, and minimizing long-term complications in patients with metabolic syndrome.