HISTOPATHOLOGICAL CHANGES OF THE PLACENTA IN PREGNANT WOMEN WITH ELEVATED HOMOCYSTEINE LEVELS AND PREECLAMPSIA

Abstract

Hyperhomocysteinemia is an independent risk factor for endothelial dysfunction and plays a critical role in the pathogenesis of preeclampsia. The combination of increased homocysteine and placental hypoxia leads to structural and vascular changes within the placenta that contribute to fetal growth restriction and maternal complications. This study aimed to examine the histopathological features of placentas obtained from preeclamptic women with elevated homocysteine levels compared with normotensive controls.