GROWTH AND DEVELOPMENT OF BONES IN CHILDREN OF EARLY PUBERTY

Authors

  • Umarova Muhabbat Zakirovna Andijan State Medical Institute

Keywords:

Bone growth, ossification, bone remodeling, skeletal development, osteogenesis, mechanical forces, bone repair, aging, bone density

Abstract

Bone growth and development are essential processes in the human body that ensure proper skeletal structure and function. Ossification, the process by which bone tissue is formed, and remodeling, the continuous reshaping of bone throughout life, are key elements of skeletal development. This article provides an overview of bone growth, ossification types, and the mechanisms of bone remodeling. Understanding these processes is crucial in areas such as orthopedics, aging, and regenerative medicine. The relationship between genetic factors, mechanical forces, and environmental influences on bone health is also explored.

References

Tsonis, P. A., et al. (2004). Regeneration of bone and its implications for human health. Journal of Clinical Investigation, 112(7), 1033-1042.

Karsenty, G., et al. (2009). Transcriptional control of bone formation by the osteoblast-specific transcription factor Runx2. Journal of Bone and Mineral Research, 24(9), 1424-1429.

Wang, W., et al. (2014). Signaling pathways in osteogenesis. Bone Research, 2(3), 190-195.

Hughes, S. M., et al. (2011). The structure and function of the epiphyseal growth plate. International Journal of Developmental Biology, 55(2), 123-133.

Colnot, C., et al. (2005). Mechanical loading regulates mesenchymal progenitor cell differentiation and ossification in the growth plate. Journal of Bone and Mineral Research, 20(4), 659-669.

Teitelbaum, S. L. (2000). Bone resorption by osteoclasts. Science, 289(5484), 1504-1508.

Ducy, P., et al. (2000). Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell, 100(2), 197-207.

Riggs, B. L., & Hartmann, L. C. (2003). Select osteoporosis: pathogenesis and therapy. New England Journal of Medicine, 349(6), 500-514.

Downloads

Published

2025-03-05

How to Cite

Umarova Muhabbat Zakirovna. (2025). GROWTH AND DEVELOPMENT OF BONES IN CHILDREN OF EARLY PUBERTY. Ethiopian International Multidisciplinary Research Conferences, 176–180. Retrieved from https://eijmr.org/conferences/index.php/eimrc/article/view/458