PATHOLOGICAL ANATOMY OF DIABETIC MACROANGIOPATHY AND ATHEROSCLEROSIS
Keywords:
Diabetes mellitus, Diabetic macroangiopathy, Atherosclerosis, Pathological anatomy, Endothelial dysfunction, Dyslipidemia, Hyperglycemia, Atherosclerotic plaque, Thrombosis, Ischemic heart diseaseAbstract
Background:
Diabetes mellitus is a chronic metabolic disorder associated with long-term vascular complications that significantly increase morbidity and mortality. Among these complications, diabetic macroangiopathy plays a central role and is closely linked to accelerated atherosclerosis affecting large and medium-sized arteries.
Objective:
This article aims to describe the pathological anatomical features of diabetic macroangiopathy and atherosclerosis, emphasizing structural changes in the arterial wall and their clinical significance.
Methods:
The study is based on a comprehensive review and analysis of classical and contemporary pathological anatomy literature, focusing on morphological changes observed in major vascular beds in patients with diabetes mellitus.
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ADA (American Diabetes Association). Cardiovascular disease and risk management. Diabetes Care, 2023.
Ganong’s Review of Medical Physiology. McGraw-Hill, 2021.
Fowler M. Microvascular and macrovascular complications of diabetes. Clinical Diabetes, 2008.
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