THE ROLE OF RENAL FUNCTION IN THE DEVELOPMENT OF ARTERIAL HYPERTENSION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: A CLINICO-PATHOPHYSIOLOGICAL STUDY
Keywords:
Type 2 diabetes; arterial hypertension; diabetic nephropathy; microalbuminuria; glomerular filtration rate; RAAS activation; renal function; endothelial dysfunction.Abstract
This article examines the role of renal dysfunction in the development of arterial hypertension in patients with type 2 diabetes mellitus. Diabetic nephropathy, glomerular hyperfiltration, microalbuminuria, activation of the renin–angiotensin–aldosterone system (RAAS), and endothelial impairment are analyzed as key mechanisms contributing to elevated blood pressure. Biochemical parameters such as serum creatinine, estimated glomerular filtration rate (eGFR), urinary albumin excretion, and markers of oxidative stress are assessed alongside clinical indicators of hypertension. The findings demonstrate that early renal impairment significantly accelerates the onset and progression of hypertension in type 2 diabetic patients through hemodynamic, hormonal, and inflammatory pathways. The study highlights the importance of integrating renal biomarkers into early risk prediction and individualized therapeutic strategies for diabetic hypertension.
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