ANTIOXIDANT AND NEUROPROTECTIVE EFFECTS OF ‘AS-SABR’ AND ‘AS-SEDAN’ IN AN ALCl₃-INDUCED NEUROTOXIC MODEL

Abstract

This study investigated the antioxidant and neuroprotective properties of the dietary supplements “As-Sabr” and “As-Sedan” based on biomarkers obtained from an aluminum chloride (AlCl₃)-induced neurotoxic model, including malondialdehyde (MDA), diene conjugates (DC), the activity of catalase and superoxide dismutase (SOD) enzymes, and total protein levels. The preparations, developed from Valeriana officinalis L., Matricaria chamomilla L., Melissa officinalis L., Urtica dioica L., Hypericum perforatum L., and Jasminum officinale L., were tested in an in vivo model. The results demonstrated that “As-Sabr” and “As-Sedan” exert neuroprotective and adaptogenic effects on the nervous system by reducing AlCl₃-induced oxidative stress, inhibiting lipid peroxidation, restoring antioxidant enzyme activity, and stabilizing protein-metabolic balance.