LINKING IMMUNE ACTIVATION TO ACUTE EVENTS IN CHRONIC HEART FAILURE PATIENTS
Keywords:
cytokines, heart failure, inflammation, IL-6, TNF-αAbstract
This study investigates the role of inflammatory cytokines in the acute decompensation of chronic heart failure (CHF). A total of 56 patients were observed over three years at the Bukhara Branch of the Republican Scientific Center for Emergency Medical Care. Cytokine profiling showed significantly elevated levels of TNF-α, IL-6, and IL-1β in acutely decompensated CHF patients compared to stable ones. These levels correlated with worsened clinical status, including higher NYHA class and NT-proBNP. The results suggest that cytokine activation is closely associated with myocardial stress and can serve as a marker for early decompensation. Targeted anti-inflammatory therapies, particularly IL-1 inhibitors, may improve outcomes. Cytokine profiling, therefore, holds promise as both a diagnostic and therapeutic tool in CHF management.
References
Pattoyevich, G. A., & Nilufar, M. (2025, June). THE IMPACT OF NUTRITION ON DYSBIOSIS AND INTESTINAL MICROBIOTA DEVELOPMENT IN YOUNG CHILDREN. In Scientific Conference on Multidisciplinary Studies (pp. 188-194).
Zarnigor, A., & Madaminov, S. M. (2025, February). MORPHOLOGICAL CHANGES IN BONES IN OSTEOPOROSIS. In Ethiopian International Multidisciplinary Research Conferences (pp. 140-142).
Ganiyeva, M. R. (2024, December). CLINICAL AND MORPHOFUNCTIONAL CHANGES IN THE RETINA IN HIGH MYOPIA IN COMBINATION WITH AGE-RELATED MACULAR DEGENERATION OF DIFFERENT STAGES. In International Conference on Modern Science and Scientific Studies (pp. 141-142).
Shevchenko, L. I., Karimov, K. Y., Alimov, T. R., Lubentsova, O. V., & Ibragimov, M. N. (2020). The effect of a new amino acid agent on protein metabolism, the intensity of lipid peroxidation and the state of the antioxidant system in experimental protein-energy deficiency. Pharmateca, 27(12), 86-90.
Zarnigor, A. (2025). SUYAK ZICHLIGI KAMAYISHI: SABABLARI, KLINIK AHAMIYATI. Лучшие интеллектуальные исследования, 47(1), 224-235.
Madaminov, S. M., & Abdullayeva, Z. (2025). MORPHOLOGICAL CHANGES IN BONES IN OSTEOPOROSIS (literature review). Ethiopian International Journal of Multidisciplinary Research, 12(01), 35-38.
Van Linthout, S., & Tschöpe, C. (2017). Inflammation—Cause or Consequence of Heart Failure or Both? Current Heart Failure Reports, 14(4), 251–265.
Van Tassell, B.W., Arena, R.A., Biondi-Zoccai, G., et al. (2013). IL-1 Blockade in Heart Failure. Heart Failure Reviews, 18, 105–113.
Gungor, B., et al. (2022). Role of IL-6 and ST2 in Heart Failure. Journal of Inflammation Research, 15, 1423–1435.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
